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Novità terapeutiche -
Angiomi
Mirella Milioto 18/12/2006
Cari colleghi
Vi invio una notizia sulla terapia degli emangiomi con imiquimod. Qualcuno ha esperienza?
Cari saluti. Mirella Milioto
Treatment of hemangiomas of infancy with imiquimod cream
Imiquimod is an immunomodulator that is currently approved for the treatment of genital warts, actinic keratoses, and superficial basal cell carcinoma. Catherine McCuaig, MD, presented preliminary data from a study that she and her colleagues at Hôpital Ste-Justine in Montreal, Canada, are performing to evaluate the efficacy of imiquimod 5% cream in the treatment of hemangiomas of infancy. The mechanism of action of this medication makes it an interesting candidate for the treatment of this condition. Imiquimod leads to the secretion by T cells of multiple antiangiogenic cytokines, including interferon-alpha (IFN-alpha), and systemic IFN-alpha is an established therapy for
hemangiomas.
A few case reports in the literature have reported the successful treatment of hemangiomas with imiquimod, including a report of a 4-month-old infant whose hemangioma completely resolved after 10 weeks, and a report of 10 patients treated for up to 16 weeks, 70% of whom achieved complete or excellent response. When reading such reports, it is important to consider the patients' ages and the duration of therapy, because hemangiomas undergo spontaneous involution, usually beginning around 9 to 12 months of
age.
The study at Hôpital Ste-Justine will be the first prospective study evaluating imiquimod in the treatment of hemangiomas of infancy. Preliminary data suggest that there is a diminution in volume as well as erythema with application of imiquimod cream 3 to 7 times per week for 16 weeks.
References
McCuaig C. A phase II study of the effect of imiquimod 5% cream on hemangioma of infancy. Program of the Society for Pediatric Dermatology 2006 Annual Meeting; July 6-9, 2006; Montreal, Canada.
Hazen PG, Carney JF, Engstrom CW, et al. Proliferating hemangioma of infancy: successful treatment with topical 5% imiquimod cream. Pediatr Dermatol. 2005;22:254-256.
Welsh O, Olazaran Z, Gomez M, et al. Treatment of infantile hemangiomas with short-term application of imiquimod 5% cream. J Am Acad Dermatol. 2004;51:639-642.
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